I think Mako needs to die. Right now she babies Ryuuko far too much.
So does Satsuki, but Ryuuko proved she is over Satsuki, and Satsuki is about to get fucked six ways to sunday.
The only way Ryuuko can rise above Mako is if Mako dies.
As it is, Mako is awkward, because she's comic relief at a time where the plot needs to become more serious